GROUP FRANKENBERG-DINKEL / Project FR1487/16-1

What is the role of cyanophage-encoded auxiliary metabolic genes in the virocell?

Marine Cyanobacteria of the genera Synechococcales and Prochlorococcales are the most abundant prokaryotic phototrophs in the world’s ocean. These Cyanobacteria are highly challenged by viral infection with up to 40 % of the bacterial population being infected by cyanophages. Infection of a bacterium by a phage transforms the host cell into a so-called virocell where both viral and host genomes are expressed in parallel. Many cyanophages genomes carry so-called auxiliary metabolic genes, often related to photosynthesis and light harvesting. Within this project we seek to understand the role of these genes and their encoded proteins in the virocell using a combination of phage genetics, biochemistry and masspectrometry based proteomics.

Figure 1: Stages of phage infection including the living state of the phage in the virocell.

Principal Investigator(s)

Prof. Dr. Nicole Frankenberg-Dinkel
Fachbereich Biologie, Abt. Mikrobiologie
Technische Universität Kaiserslautern

E-Mail: nfranken@bio.uni-kl.de
Homepage: https://www.bio.uni-kl.de/mikrobiologie/forschung/

 

PhD student(s)

Helen Wegner (hwegner@bio.uni-kl.de)

Publications

  • Ledermann, B., Beja, O. & Frankenberg-Dinkel, N. (2016) New biosynthetic pathway for pink pigments from uncultured oceanic viruses. Environ. Microbiol. 18, 4337-4347.