SPP 2330

GROUP LINDELL & STEGLICH / Project LI 2179/1-1 | STE 1119/8-1

Novel anti-phage resistance mechanisms channeled through transcriptional regulation

Marine unicellular cyanobacteria of the genera Synechococcus and Prochlorococcus are important primary producers in the world’s oceans. Their coexistence with high abundances of cyanophages is likely due to effective mechanisms of resistance.

This project will address the central question of how the phage transcriptional program of marine T4-like cyanophages is regulated in sensitive cyanobacteria and to elucidate the mechanisms of defence that function at the transcriptional level in resistant cyanobacteria.

This study will provide fundamental information on the novel means through which the marine T4-like cyanophages regulate their transcriptional program relative to that in the T4 archetype. Furthermore, this will lay the groundwork for the discovery of new anti-viral defence systems that function at the transcriptional level. As such this research program will open up new horizons in the understanding of host-virus interactions in this ecologically important group of organisms.

Principal Investigator(s)

Prof. Dr. Debbie Lindell
Technion – Israel Institute of Technology
Faculty of Biology
Dresner Chair in Life Sciences and Medicine

E-Mail: dlindell@technion.ac.il
Homepage: https://lindelltechnion.wixsite.com/lindell-lab

Dr. Claudia Steglich
University of Freiburg
Institute of Biology 3, Genetics & Experimental Bioinformatics

E-Mail: claudia.steglich@biologie.uni-freiburg.de
Homepage: http://www.cyanolab.de/index.php

PhD student(s)

Christina Soon (christina.soon@biologie.uni-freiburg.de) – Steglich lab

Graduate student(s)

Maor Berkovich (maor.b@campus.technion.ac.il) – Lindell lab


  • *Doron S., *Fedida A., Hernández-Prieto M.A., Sabehi G., Karunker I., Stazic D., Feingersch R., Steglich C., Futschik M., #Lindell D. and #Sorek R. (2015) Transcriptome dynamics of a broad host-range cyanophage and its hosts. ISME J 10, https://doi.org/10.1038/ismej.2015.210. *contributed equally, #corresponding authors
  • Zborowsky, S. and D. Lindell. (2019) Resistance in marine cyanobacteria differs against specialist and generalist cyanophages. Proc. Nat. Acad. Sci. USA. 116:16899-16908, www.pnas.org/cgi/doi/10.1073/pnas.1906897116.