Phages encode the most diverse protein sequence space and represent an untapped reservoir of novel factors. We are investigating novel phage factors from jumbo phages >200 kB in genome size, such as ΦKZ, which infect Pseudomonas. To unlock phage ingenuity, we integrate state-of-the-art high-throughput multi-omics, functional screening and microscopy to elucidate the complex lifestyle of jumbo phages, a playground for discovery. We aim to investigate novel mechanisms of gene expression control in jumbo phage-infected cells. We aim to understand host-phage interactions in the context of cellular organisation and regulatory mechanisms under non-standard growth conditions such as nutrient limitation, and to extend our view to non-model strains such as clinical and environmental isolates with specialised stress responses. Our research aims to contribute to novel phage-based therapeutic approaches to combat antimicrobial resistance