GROUP DEBARBIEUX & STECHER / Associated Project
Mechanisms underlying bacteriophages and bacteria stable coexistence and its consequences on gut microbiome function
Bacteriophages are important effectors and indicators of human health and disease by managing specific bacterial population structures and by interacting with the mucosal immune system. Despite metagenome-based studies have addressed their abundance, diversity and stability over time in the gut, little in known on the role of bacteriophages in intestinal microbiota homeostasis and its impact on global microbiome functions. Furthermore, there is a gap in knowledge pertaining to the mechanisms by which bacteriophages and their bacterial hosts dynamically interact over time.
In this project, we will conduct an in-depth characterization of bacteriophage ecology and study their influence on the microbiome and related functions in the gut, using gnotobiotic mice colonized with a synthetic bacterial community, the Oligo-Mouse-Microbiota (OMM12). In addition, we will study the mechanisms underlying stable coexistence of bacteriophages and their host bacteria in the gut. The final goal is to refine strategies for bacteriophage-based intestinal microbiota engineering.
Figure 1: The uneven spatial distribution of bacteriophages in the gut creates bacterial refuges, which may hinder the overall efficacy of phage therapy targeting intestinal pathogens.
Bacteriophage, Bacterium, Host Laboratory
Max von Pettenkofer Institute
Devon Conti, firstname.lastname@example.org
Caroline Henrot, email@example.com
Luís Leónidas Cardoso, firstname.lastname@example.org